Xenograft models for pediatric cancer therapies

Mouse xenograft models vs GEM models for human cancer therapeutics.

Pharmacologic Therapies for Pediatric Concussions

CONTEXT Pediatric concussions are common, and emphasis on correct diagnosis and management is stressed in consensus guidelines. Medications may have a role in management of concussion, but no consensus exists regarding appropriate pharmacologic therapy. EVIDENCE ACQUISITION Nonsystematic review. STUDY DESIGN Clinical review. LEVEL OF EVIDENCE Level 4. RESULTS There is limited evidence f...

Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies.

Continuous xenografts from 10 children with acute lymphoblastic leukemia (ALL) were established in nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice. Relative to primary engrafted cells, negligible changes in growth rates and immunophenotype were observed at second and third passage. Analysis of clonal antigen receptor gene rearrangements in 2 xenografts from patients at diagnos...

Xenograft assessment of predictive biomarkers for standard head and neck cancer therapies

Head and neck squamous cell carcinoma (HNSCC) remains a challenging cancer to treat with overall 5-year survival on the order of 50-60%. Therefore, predictive biomarkers for this disease would be valuable to provide more effective and individualized therapeutic approaches for these patients. While prognostic biomarkers such as p16 expression correlate with outcome; to date, no predictive biomar...

Gonadotoxicity of Cancer Therapies in Pediatric and Reproductive-Age Males

Recent epidemiological studies estimate that approximately 1 in every 1,300 young males in the United States is a childhood cancer survivor [ 1 ] . Of this population, approximately 30% received gonadotoxic cancer treatments that resulted in permanent infertility [ 2 ] . Therefore, approximately 1 in every 5,000 young males is at risk for infertility due to their pediatric cancer treatment. Thi...